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KMID : 0191119980130030286
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Journal of Korean Medical Science
1998 Volume.13 No. 3 p.286 ~ p.290
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Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer
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Ko BK
Cho HR/Choi DW/Nam CW/Park CJ/Kim GY/Kim SS/Woo YJ/Huh J/Kim MY
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Abstract
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The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis of human
cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes and their
inhibitor (TIMP-2) constitute promising targets in the development of anticancer therapies. In order to
investigate the correlation between expressions of TIMP-2, MMPs and clinical outcome, immunohistochemical
staining of MMP-2, MMP-9, and TIMP-2 were performed on paraffin-embedded tissue sections of 15 early gastric
cancers (EGC) and 15 advanced gastric carcinomas (AGC) without nodal metastasis and 15 AGC with nodal
metastasis (AGCn+). MMP-2 and MMP-9 were expressed in neoplastic cell plasma membrane in 83.3% and 88% of
cases of AGC, respectively with inter-tumoral variability of staining intensity. MMP-2 and MMP-9 staining
were not correlated with presence of nodal metastasis or degree of invasion depth at the time of diagnosis
(p>0.05). The immunoreactivity of TIMP-2 was detected in the peri-tumoral stroma. Residual benign stomach
tissue showed no or weak immunoreactivity for TIMP-2 staining. Among AGC, neoplasms with diffuse and strong
TIMP-2 staining have less frequent metastasis (28.6%) than cases with focal and weak (68.8%) (p<0.05). Early
gastric cancer revealed diffuse and strong TIMP-2 expressions. We conclude that clinical outcome such as
depth of invasion or metastasis is more closely related to the expression of TIMP-2 than the corresponding
MMPs.
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KEYWORD
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